{"id":165616,"date":"2021-10-01T11:59:37","date_gmt":"2021-10-01T09:59:37","guid":{"rendered":"https:\/\/climatescience.press\/?p=165616"},"modified":"2021-10-01T11:59:39","modified_gmt":"2021-10-01T09:59:39","slug":"long-term-dangers-of-experimental-mrna-shots","status":"publish","type":"post","link":"https:\/\/climatescience.press\/?p=165616","title":{"rendered":"Long-Term Dangers Of Experimental MRNA Shots"},"content":{"rendered":"\n
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\u201cLet\u2019s start with a thought experiment: <\/p>\n\n\n\n

If an engineering design flaw exists and no one measures it, can it really injure people or kill them?\u201d a Twitter user named Ehden writes.1<\/sup>\u00a0He goes on to discuss an overlooked aspect of the COVID mRNA shots, something called \u201ccodon optimization,\u201d which virtually guarantees unexpected results.<\/p>\n\n\n\n

Ehden explains:2<\/sup><\/p>\n\n\n\n

\u201cTrying to tell your body to generate proteins is hard for many reasons. One of them is the fact that when you try to run the protein information via ribosomes which process that code and generate the protein, it can be very slow or can get stuck during the process.<\/em><\/p><\/blockquote>\n\n\n\n

Luckily, scientists found a way to overcome this problem, by doing code substitution: instead of using the original genetic code to generate the protein, they changed the letters in the code so the code would be optimized. This is known as Codon Optimization.\u201d<\/em><\/p><\/blockquote>\n\n\n\n

COVID Shots Use Codon Optimization<\/h4>\n\n\n\n

A codon consists of three nucleotides, and nucleotides are the building blocks of DNA. An August 2021 article in Nature Reviews Drug Discovery, addressed the use of codon optimization as follows:3<\/sup><\/p>\n\n\n\n

\u201cThe open reading frame of the mRNA vaccine is the most crucial component because it contains the coding sequence that is translated into protein.<\/em><\/p><\/blockquote>\n\n\n\n

Although the open reading frame is not as malleable as the non-coding regions, it can be optimized to increase translation without altering the protein sequence by replacing rarely used codons with more frequently occurring codons that encode the same amino acid residue.<\/em><\/p><\/blockquote>\n\n\n\n

For instance, the biopharmaceutical company CureVac AG discovered that human mRNA codons rarely have A or U at the third position and patented a strategy that replaces A or U at the third position in the open reading frame with G or C. CureVac used this optimization strategy for its SARS-CoV-2 candidate CVnCoV \u2026<\/em><\/p>

Although replacement of rare codons is an attractive optimization strategy, it must be used judiciously. This is because, in the case of some proteins, the slower translation rate of rare codons is necessary for proper protein folding.<\/em><\/p>

To maximize translation, the mRNA sequence typically incorporates modified nucleosides, such as pseudouridine, N1-methylpseudouridine or other nucleoside analogues. Because all native mRNAs include modified nucleosides, the immune system has evolved to recognize unmodified single-stranded RNA, which is a hallmark of viral infection.<\/em><\/p>

Specifically, unmodified mRNA is recognized by pattern recognition receptors, such as Toll-like receptor 3 (TLR3), TLR7 and TLR8, and the retinoic acid-inducible gene I (RIGI) receptor. TLR7 and TLR8 receptors bind to guanosine- or uridine-rich regions in mRNA and trigger the production of type I interferons, such as IFN\u03b1, that can block mRNA translation.<\/em><\/p>

The use of modified nucleosides, particularly modified uridine, prevents recognition by pattern recognition receptors, enabling sufficient levels of translation to produce prophylactic amounts of protein.<\/em><\/p>

Both the Moderna and Pfizer\u2013BioNTech SARS-CoV-2 vaccines \u2026 contain nucleoside-modified mRNAs. Another strategy to avoid detection by pattern recognition receptors, pioneered by CureVac, uses sequence engineering and codon optimization to deplete uridines by boosting the GC content of the vaccine mRNA.\u201d<\/em><\/p><\/blockquote>\n\n\n\n

Much of this information was previously reviewed in my interview with Stephanie Seneff, Ph.D., and Judy Mikovits, Ph.D. You can\u2019t see the article but the video is embedded above. This study was published well after our interview and merely confirms what Seneff and Mikovits have unraveled in their research.<\/p>\n\n\n\n

According to Ehden, 60.9 percent of the codons in COVID shots have been optimized, equivalent to 22.5 percent of the nucleotides, but he doesn\u2019t specify which shot he\u2019s talking about, or exactly where the data came from.<\/p>\n\n\n\n

That all mRNA COVID shots are using codon optimization to one degree or another is clear, however. A July 2021 article4<\/sup> in the journal Vaccines specifically evaluates and comments on the Pfizer\/BioNTech and Moderna mRNA shots, noting:<\/p>\n\n\n\n

The design of Pfizer\/BioNTech and Moderna mRNA vaccines involves many different types of optimizations \u2026 The mRNA components of the vaccine need to have a 5\u2032-UTR to load ribosomes efficiently onto the mRNA for translation initiation, optimized codon usage for efficient translation elongation, and optimal stop codon for efficient translation termination.<\/em><\/p><\/blockquote>\n\n\n\n

Both 5\u2032-UTR and the downstream 3\u2032-UTR should be optimized for mRNA stability. The replacement of uridine by N1-methylpseudourinine (\u03a8) complicates some of these optimization processes because \u03a8 is more versatile in wobbling than U. Different optimizations can conflict with each other, and compromises would need to be made.<\/em><\/p><\/blockquote>\n\n\n\n

I highlight the similarities and differences between Pfizer\/BioNTech and Moderna mRNA vaccines and discuss the advantage and disadvantage of each to facilitate future vaccine improvement. In particular, I point out a few optimizations in the design of the two mRNA vaccines that have not been performed properly.\u201d<\/em><\/p><\/blockquote>\n\n\n\n

What Can Go Wrong?<\/h4>\n\n\n\n

One key take-home from the Nature Reviews Drug Discovery article5<\/sup> cited above is that replacing rare codons \u201cmust be used judiciously,\u201d as rarer codons can have slower translation rates and a slowed-down rate is actually necessary to prevent protein misfolding.The spike protein is the toxic part of the virus responsible for the most unique effects of the virus, such as the blood clotting disorders, neurological problems and heart damage. To expect the COVID shot to not produce these kinds of effects would be rather na\u00efve.<\/p>\n\n\n\n

A (adenine) and U (uracil) in the third position are rare, and the COVID shots replace these A\u2019s and U\u2019s with G\u2019s (guanine) or C\u2019s (cytosine). According to Seneff, this switch results in a 1,000-fold greater amount of spike protein compared to being infected with the actual virus.<\/p>\n\n\n\n

What could go wrong? Well, just about anything. Again, the shot induces spike protein at levels unheard of in nature (even if SARS-CoV-2 is a \u201csouped up\u201d manmade concoction), and the spike protein is the toxic part of the virus responsible for the most unique effects of the virus, such as the blood clotting disorders, neurological problems and heart damage.<\/p>\n\n\n\n

So, to expect the COVID shot to not produce these kinds of effects would be rather na\u00efve. The codon switches might also result in protein misfolding, which is equally bad news. As explained by Seneff in our previous interview:<\/p>\n\n\n\n

The spike proteins that these mRNA vaccines are producing \u2026 aren\u2019t able to go into the membrane, which I think is going to encourage it to become a problematic prion protein. Then, when you have inflammation, it upregulates alpha-synuclein [a neuronal protein that regulates synaptic traffic and neurotransmitter release].<\/em><\/p><\/blockquote>\n\n\n\n

So, you\u2019re going to get alpha-synuclein drawn into misfolded spike proteins, turning into a mess inside the dendritic cells in the germinal centers in the spleen. And they\u2019re going to package up all this crud into exosomes and release them. They\u2019re then going to travel along the vagus nerve to the brainstem and cause things like Parkinson\u2019s disease.<\/em><\/p><\/blockquote>\n\n\n\n

So, I think this is a complete setup for Parkinson\u2019s disease \u2026 It\u2019s going to push forward the date at which someone who has a propensity towards Parkinson\u2019s is going to get it.<\/em><\/p>

And it\u2019s probably going to cause people to get Parkinson\u2019s who never would have gotten it in the first place \u2014 especially if they keep getting the vaccine every year. Every year you do a booster, you bring the date that you\u2019re going to get Parkinson\u2019s ever closer.\u201d<\/em><\/p><\/blockquote>\n\n\n\n

Immune Dysfunction And Viral Flare-Ups<\/h4>\n\n\n\n

Other significant threats include immune dysfunction and the flare-up of latent viral infections, which is something Mikovits has been warning about. In our previous interview, she noted:<\/p>\n\n\n\n

\u201cWe use poly(I:C) [a toll-like receptor 3 agonist] to signal the cell to turn on the type I interferon pathway, and because [the spike protein your body produces in response to the COVID shot] is an unnatural synthetic envelope, you\u2019re not seeing poly(I:C), and you\u2019re not [activating] the Type I interferon pathway.<\/em><\/p><\/blockquote>\n\n\n\n

You\u2019ve bypassed the plasmacytoid dendritic cell, which combined with IL-10, by talking to the regulatory B cells, decides what subclasses of antibodies to put out. So, you\u2019ve bypassed the communication between the innate and adaptive immune response. You now miss the signaling of the endocannabinoid receptors \u2026<\/em><\/p>

A large part of Dr. [Francis] Ruscetti\u2019s and my work over the last 30 years has been to show you don\u2019t need an infectious transmissible virus \u2014 just pieces and parts of these viruses are worse, because they also turn on danger signals. They act like danger signals and pathogen-associated molecular patterns.<\/em><\/p>

So, it synergistically leaves that inflammatory cytokine signature on that spins your innate immune response out of control. It just cannot keep up with the myelopoiesis [the production of cells in your bone marrow]. Hence you see a skew-away from the mesenchymal stem cell towards TGF-beta regulated hematopoietic stem cells.<\/em><\/p>

This means you could see bleeding disorders on both ends. You can\u2019t make enough firetrucks to send to the fire. Your innate immune response can\u2019t get there, and then you\u2019ve just got a total train wreck of your immune system.\u201d<\/em><\/p><\/blockquote>\n\n\n\n

We\u2019re now seeing reports of herpes and shingles infection following COVID-19 injection, and this is precisely what you can expect if your Type I interferon pathway is disabled. That\u2019s not the end of your potential troubles, however, as these coinfections could accelerate other diseases as well.<\/p>\n\n\n\n

For example, herpes viruses have been implicated as a trigger of both AIDS6<\/sup> and myalgic encephalomyelitis7<\/sup> (chronic fatigue syndrome or ME-CFS). According to Mikovits, these diseases don\u2019t appear until viruses from different families partner up and retroviruses take out the Type 1 interferon pathway. Long term, the COVID mass injection campaign may be laying the foundation for a rapidly approaching avalanche of a wide range of debilitating chronic illnesses.<\/p>\n\n\n\n

Are COVID Shots Appropriately Optimized?<\/h4>\n\n\n\n

As noted in the Vaccines article cited earlier, the codon optimization in the Pfizer and Moderna shots could be problematic:8<\/sup><\/p>\n\n\n\n

\u201cAs mammalian host cells attack unmodified exogeneous RNA, all U nucleotides were replaced by N1-methylpseudouridine (\u03a8). However, \u03a8 wobbles more in base-pairing than U and can pair not only with A and G, but also, to a lesser extent, with C and U.<\/em><\/p><\/blockquote>\n\n\n\n

This is likely to increase misreading of a codon by a near-cognate tRNA. When nucleotide U in stop codons was replaced by \u03a8, the rate of misreading of a stop codon by a near-cognate tRNAs increased.<\/em><\/p><\/blockquote>\n\n\n\n

Such readthrough events would not only decrease the number of immunogenic proteins, but also produce a longer protein of unknown fate with potentially deleterious effects \u2026<\/em><\/p>

The designers of both vaccines considered CGG as the optimal codon in the CGN codon family and recoded almost all CGN codons to CGG \u2026 [M]ultiple lines of evidence suggest that CGC is a better codon than CGG. The designers of the mRNA vaccines (especially mRNA-1273) chose a wrong codon as the optimal codon.\u201d<\/em><\/p><\/blockquote>\n\n\n\n

The paper also points out the importance of vaccine mRNA to be translated accurately and not merely effectively, because if the wrong amino acids are incorporated, it can confuse your immune system and prevent it from identifying the correct targets.<\/p>\n\n\n\n

Accuracy is also important in translation termination, and here it comes down to selecting the correct stop codons. Stop codons (UAA, UAG or UGA), when present at the end of an mRNA coding sequence signals the termination of protein synthesis.<\/p>\n\n\n\n

According to the author, both Pfizer and Moderna selected less than optimal stop codons. \u201cUGA is a poor choice of a stop codon, and UGAU in Pfizer\/BioNTech and Moderna mRNA vaccines could be even worse,\u201d she says.<\/p>\n\n\n\n

What Health Problems Can We Expect To See More Of?<\/h4>\n\n\n\n

While the variety of diseases we may see a rise in as a result of this vaccination campaign are myriad, some general predictions can be made. We\u2019ve already seen a massive uptick in blood clotting disorders, heart attacks and stroke, as well as heart inflammation.<\/p>\n\n\n\n

More long term, Seneff believes we\u2019ll see a significant rise in cancer, accelerated Parkinson\u2019s-like diseases, Huntington\u2019s disease, and all types of autoimmune diseases and neurodegenerative disorders.<\/p>\n\n\n\n

Mikovits also suspects many will develop chronic and debilitating diseases and will die prematurely. At highest risk, she places those who are asymptomatically infected with XMRVs and gammaretroviruses from contaminated conventional vaccines. The COVID shot will effectively accelerate their death by crippling their immune function. \u201cThe kids that are highly vaccinated, they\u2019re ticking time bombs,\u201d Mikovits said in my May 2021 interview.<\/p>\n\n\n\n

What Are The Options?<\/h4>\n\n\n\n

While all of this is highly problematic, there is hope. From my perspective, I believe the best thing you can do is to build your innate immune system. To do that, you need to become metabolically flexible and optimize your diet. You\u2019ll also want to make sure your vitamin D level is optimized to between 60 ng\/mL and 80 ng\/mL (100 nmol\/L to 150 nmol\/L).<\/p>\n\n\n\n

I also recommend time-restricted eating, where you eat all your meals for the day within a six- to eight-hour window. Time-restricted eating will also upregulate autophagy, which may help digest and remove spike protein. Avoid all vegetable oils and processed foods. Focus on certified-organic foods to minimize your glyphosate exposure.<\/p>\n\n\n\n

Sauna therapy may also be helpful. It upregulates heat shock proteins, which can help refold misfolded proteins. They also tag damaged proteins and target them for removal.<\/p>\n\n\n\n

See more here:\u00a0vervetimes.com<\/a><\/p>\n\n\n\n

<\/p>\n\n\n\n

via Principia-Scientific<\/span><\/em><\/strong><\/p>\n\n\n\n

September 30, 2021<\/em> \u00a0by vervetimes.com<\/p>\n\n\n\n

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Long-Term Dangers of Experimental mRNA Shots<\/a><\/blockquote>